The Philadelphia Eagles won the game but lost receiver DeSean Jackson and right tackle Lane Johnson to injuries in Thursday night's 22-21 comeback against the New York Giants.
Making his first appearance since Week 3, Jackson caught three passes for 34 yards and rushed once for 12 yards before being tackled awkwardly on a punt return with 2:09 left in the game.
An MRI Friday confirmed a high-ankle sprain and the Eagles will place the three-time Pro Bowl selection on injured reserve, the NFL Network reported. He would be eligible to return in late November.
Jackson, 33, posted a photo Thursday night to his Instagram stories of himself wearing a walking boot on his right leg with the words, "Pray for me y'all!!"
Jackson, by far Philadelphia's most experienced wideout with more than 10,000 career yards, had missed the previous three games with a hamstring injury.
An MRI on Johnson's knee confirmed the Eagles' initial diagnosis of a grade 1 MCL sprain, per the NFL Network.
It isn't known yet whether Johnson, 30, will be available on Nov. 1 when the Eagles (2-4-1) host the Dallas Cowboys (2-4). Philadelphia then has a bye in Week 9.
Johnson, a three-time Pro Bowl pick and 2017 first-team All-Pro, had been dealing with ankle issues for most of the season before suffering this latest setback.
--Field Level Media